SCHEMBL6534709

SCHEMBL6534709

CCC(=O)N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 0.33
HDAC1 Q13547 2/20 0.33
HDAC2 Q92769 2/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA7 P43166 1/20 0.33
CA14 Q9ULX7 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
CASR P41180 1/20 0.31
CYP2D6 P10635 1/20 0.31
ALDH1A1 P00352 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
NR1D1 P20393 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
HTT P42858 1/20 0.30
DGAT1 O75907 1/20 0.30
HDAC3 O15379 1/20 0.30
HDAC8 Q9BY41 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10076053 0.82 CA12 (0.40) HDAC6HDAC1HDAC2CA12CA1
SCHEMBL1742305 0.82 AKT1 (0.39) HDAC6HDAC1HDAC2L3MBTL1CASR
SCHEMBL782398 0.82 CA14 (0.32) HDAC6HDAC1HDAC2CA14CASR
SCHEMBL13110654 0.80 CA14 (0.34) HDAC6HDAC1HDAC2CA12CA1
SCHEMBL9893327 0.79 PHF8 (0.39) HDAC6HDAC1HDAC2CASRALDH1A1
SCHEMBL28409176 0.78 CA14 (0.41) HDAC6HDAC1HDAC2CA12CA1
SCHEMBL15143768 0.78 HDAC6 (0.34) HDAC6HDAC1HDAC2CASRCYP2D6
SCHEMBL7176207 0.78 DGAT1 (0.34) HDAC6HDAC1HDAC2CA12CA1
SCHEMBL1688812 0.78 CA14 (0.38) HDAC6HDAC1HDAC2CA12CA1
SCHEMBL782292 0.77 CTSS (0.35) ALDH1A1CTSLCTSBCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0941120-A4 BRANCHED PEPTIDE LINKERS BRISTOL MYERS SQUIBB CO (US) 2004-08-18 EP disclosed
EP-0941120-A1 BRANCHED PEPTIDE LINKERS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-09-15 EP disclosed
WO-1998019705-A1 BRANCHED PEPTIDE LINKERS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-05-14 WO disclosed