SCHEMBL6534711

SCHEMBL6534711

CC(C)(C)OC(=O)CC(C)(CC(=O)OC(C)(C)C)C(N)=O

nearest known ligand 0.33

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
DGAT1 O75907 1/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
MTNR1A P48039 1/20 0.31
MTNR1B P49286 1/20 0.31
TSHR P16473 1/20 0.31
CYP2C19 P33261 1/20 0.31
HIF1A Q16665 1/20 0.31
CA12 O43570 1/20 0.31
CA2 P00918 1/20 0.31
CA14 Q9ULX7 1/20 0.31
STING1 Q86WV6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2916154 0.80 STING1 (0.33) CYP2D6MAOAMAOBDGAT1HDAC3
SCHEMBL31238586 0.76 HDAC3 (0.37) CYP2D6MAOAMAOBDGAT1HDAC3
SCHEMBL7826803 0.76 DGAT1 (0.34) CYP2D6MAOAMAOBDGAT1HDAC3
SCHEMBL5856956 0.76 MAOA (0.35) CYP2D6MAOAMAOBDGAT1HDAC3
SCHEMBL19743162 0.76 MAOA (0.32) CYP2D6MAOAMAOBDGAT1HDAC3
SCHEMBL4553890 0.75 DGAT1 (0.37) CYP2D6DGAT1HDAC3HDAC1HDAC2
SCHEMBL28832570 0.74 DGAT1 (0.33) CYP2D6MAOAMAOBDGAT1HDAC3
SCHEMBL13992301 0.74 DGAT1 (0.39) CYP2D6DGAT1HDAC3HDAC1HDAC2
SCHEMBL10939959 0.73 HMGCR (0.48) CYP2D6DGAT1HDAC3HDAC1HDAC2
SCHEMBL10339934 0.73 DGAT1 (0.36) CYP2D6DGAT1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0941120-A4 BRANCHED PEPTIDE LINKERS BRISTOL MYERS SQUIBB CO (US) 2004-08-18 EP disclosed
EP-0941120-A1 BRANCHED PEPTIDE LINKERS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-09-15 EP disclosed
WO-1998019705-A1 BRANCHED PEPTIDE LINKERS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-05-14 WO disclosed