Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | ACP1 | P24666 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.52 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.52 |
| ▸ | PNPO | Q9NVS9 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SGPL1 | O95470 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43880 | 0.89 | ESR1 (0.64) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL29384180 | 0.89 | ESR1 (0.64) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| Water SCHEMBL371432 | 0.88 | ESR1 (0.63) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| Ammonia Solution, Strong SCHEMBL31241292 | 0.88 | ESR1 (0.63) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| Hydrochloric Acid SCHEMBL14331173 | 0.88 | ESR1 (0.63) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL4576792 | 0.84 | KDM4E (0.58) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL140749 | 0.81 | HPGD (0.61) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL4576787 | 0.80 | KDM4E (0.56) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL22857703 | 0.80 | HPGD (0.56) | HPGDKDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL29040292 | 0.80 | HPGD (0.59) | HPGDKDM4EALDH1A1HSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040121988-A1 | Treatment of cerebrovascular disease | MEDICURE INTERNATIONAL INC. (BB) | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121988-A1 | Treatment of cerebrovascular disease | PNPO, PLPBP, PDXK | HPGD 242/4885KDM4E 1621/4885ALDH1A1 1627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.