Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13659627 | 0.98 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL7998637 | 0.87 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL25738350 | 0.83 | PTGS2 (0.71) | PTGS2 | |
| SCHEMBL11691415 | 0.83 | PTGS2 (0.71) | PTGS2 | |
| SCHEMBL13659592 | 0.83 | PTGS2 (0.72) | PTGS2 | |
| SCHEMBL26068017 | 0.82 | PTGS2 (0.71) | PTGS2 | |
| SCHEMBL5316867 | 0.80 | PTGS2 (0.66) | PTGS2 | |
| SCHEMBL14273054 | 0.79 | PTGS2 (0.79) | PTGS2 | |
| SCHEMBL13655586 | 0.78 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL3842943 | 0.78 | PTGS2 (1.00) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958275-A4 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | UNIV VANDERBILT (US) | 2004-12-01 | — | — | EP | disclosed |
| EP-1282423-A2 | PREVENTION OF INSULIN-DEPENDENT DIABETES, COMPLICATIONS THEREOF, OR ALLOGRAFT REJECTION BY INHIBITION OF CYCLOOXYGENASE-2 ACTIVITY WITH NS398 OR PDTC | Oklahoma Medical Research Foundation (US) | 2003-02-12 | — | — | EP | disclosed |
| US-20030017148-A1 | Prevention of insulin-dependent diabetes, complications thereof, or allograft rejection by inhibition of cyclooxygenase-2 activity | OKLAHOMA MEDICAL RESEARCH FOUNDATION | 2003-01-23 | — | — | US | disclosed |
| WO-2001085175-A2 | PREVENTION OF INSULIN-DEPENDENT DIABETES, COMPLICATIONS THEREOF, OR ALLOGRAFT REJECTION BY INHIBITION OF CYCLOOXYGENASE-2 ACTIVITY WITH NS398 OR PDTC | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2001-11-15 | — | — | WO | disclosed |
| US-6284918-B1 | ENZYME INHIBITORS | VANDERBILT UNIVERSITY | 2001-09-04 | — | — | US | disclosed |
| EP-0958275-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5973191-A | AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE | VANDERBILT UNIVERSITY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998029382-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1998-07-09 | — | — | WO | disclosed |