Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | TTK | P33981 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.58 |
| ▸ | ACVR1 | Q04771 | 10/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.50 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.50 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.50 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535381 | 0.90 | ACVR1 (0.55) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL23164291 | 0.79 | MAPK14 (0.57) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL29830973 | 0.79 | MAPK14 (0.57) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL6535782 | 0.76 | MCL1 (0.50) | MAPK14CA12PARP1CA9KDM4E | |
| SCHEMBL27917128 | 0.74 | CYP1A2 (0.60) | TGFBR1NFATC1DYRK1ASMN1; SMN2NPC1 | |
| SCHEMBL29699887 | 0.74 | CYP1A2 (0.60) | TGFBR1NFATC1DYRK1ASMN1; SMN2NPC1 | |
| SCHEMBL1227713 | 0.74 | CYP1A2 (0.60) | TGFBR1NFATC1DYRK1ASMN1; SMN2NPC1 | |
| SCHEMBL7351998 | 0.73 | AURKA (0.71) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL6535826 | 0.73 | CHEK1 (0.46) | TGFBR1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL30487734 | 0.72 | CYP1A2 (0.58) | TGFBR1NFATC1DYRK1ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261338-A4 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR INC (US) | 2004-05-06 | — | — | EP | claimed |
| EP-1261338-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | Cymar, Inc. (US) | 2002-12-04 | — | — | EP | claimed |
| WO-2001062253-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR, INC. (US) | 2001-08-30 | — | — | WO | claimed |
| EP-1261338-A4 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR INC (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1261338-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | Cymar, Inc. (US) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062253-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR, INC. (US) | 2001-08-30 | — | — | WO | disclosed |