Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.71 |
| ▸ | TTK | P33981 | 1/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.71 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.71 |
| ▸ | ACVR1 | Q04771 | 10/20 | 0.56 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351074 | 0.80 | AURKA (0.67) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL10962813 | 0.80 | AURKA (0.67) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL10961477 | 0.79 | AURKA (0.69) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL15070816 | 0.78 | AURKA (0.63) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL10962545 | 0.77 | AURKA (0.62) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL18155092 | 0.76 | NPC1 (0.66) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL6535142 | 0.73 | AURKA (0.58) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL10961705 | 0.73 | ACVR1 (0.58) | AURKATTKAURKBINCENPACVR1 | |
| SCHEMBL1888457 | 0.72 | PRMT5 (0.43) | AURKATTKAURKBINCENPSMN1; SMN2 | |
| SCHEMBL16160810 | 0.71 | ALDH1A1 (0.41) | AURKATTKAURKBINCENPSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0118528-A4 | 5-(BICYCLIC NITROGEN-HETEROARYL)PYRID-2-ONES AND THEIR USE FOR INCREASING CARDIAC CONTRACTILITY. | RORER INTERNAT OVERSEAS INC (US) | 1985-09-09 | — | — | EP | claimed |
| EP-0118528-A1 | 5-(BICYCLIC NITROGEN-HETEROARYL)PYRID-2-ONES AND THEIR USE FOR INCREASING CARDIAC CONTRACTILITY | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-09-19 | — | — | EP | claimed |
| WO-1984000756-A1 | 5 (BICYCLIC NITROGEN-HETEROARYL)PYRID-2-ONES AND THEIR USE FOR INCREASING CARDIAC CONTRACTILLITY | RORER INT OVERSEAS (US) | 1984-03-01 | — | — | WO | claimed |
| US-5141931-A | 5-Quinolinylpyridinones, cardiotonic compositions and methods | STERLING WINTHROP INC. (US) | 1992-08-25 | — | — | US | disclosed |