Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882316 | 0.79 | AURKA (0.50) | CHEK1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL16456296 | 0.78 | TNKS (0.55) | CHEK1NPC1RAB9AMITFMAPT | |
| SCHEMBL924667 | 0.76 | AXL (0.49) | NPC1RAB9AMAPTKDM4EPOLB | |
| SCHEMBL14446919 | 0.74 | BTK (0.46) | CHEK1NPC1RAB9AMITFMAPT | |
| SCHEMBL6535526 | 0.74 | AR (0.54) | NPC1RAB9AMAPTKDM4ELMNA | |
| SCHEMBL8675092 | 0.73 | ALDH1A1 (0.56) | CHEK1NPC1RAB9AMETBRD4 | |
| SCHEMBL6535142 | 0.73 | AURKA (0.58) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2096438 | 0.73 | PRKCI (0.47) | CHEK1NPC1RAB9AMAPTMET | |
| SCHEMBL3423163 | 0.72 | KDM4E (0.50) | NPC1RAB9AMAPTKDM4ELMNA | |
| SCHEMBL11019342 | 0.72 | CHEK1 (0.38) | CHEK1NPC1RAB9AMITFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261338-A4 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR INC (US) | 2004-05-06 | — | — | EP | claimed |
| EP-1261338-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | Cymar, Inc. (US) | 2002-12-04 | — | — | EP | claimed |
| WO-2001062253-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR, INC. (US) | 2001-08-30 | — | — | WO | claimed |
| EP-1261338-A4 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR INC (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1261338-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | Cymar, Inc. (US) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062253-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR, INC. (US) | 2001-08-30 | — | — | WO | disclosed |