Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6249151 | 0.83 | PTGS2 (0.56) | PTGS2POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL6250374 | 0.83 | PTGS2 (0.44) | PTGS2POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL6984241 | 0.83 | PTGS2 (0.44) | PTGS2POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL6251303 | 0.82 | PTGS2 (0.41) | PTGS2POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL9351941 | 0.80 | POLB (0.49) | PTGS2POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL6251306 | 0.79 | PTGS2 (0.55) | PTGS2TDP1TSHRKDM4EHPGD | |
| SCHEMBL6251308 | 0.79 | PTGS2 (0.41) | PTGS2POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL6031819 | 0.78 | PTGS2 (0.62) | PTGS2TDP1TSHRKDM4EHPGD | |
| SCHEMBL9351756 | 0.78 | POLB (0.47) | PTGS2POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL13659592 | 0.77 | PTGS2 (0.72) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958275-A4 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | UNIV VANDERBILT (US) | 2004-12-01 | — | — | EP | disclosed |
| US-6284918-B1 | ENZYME INHIBITORS | VANDERBILT UNIVERSITY | 2001-09-04 | — | — | US | disclosed |
| EP-0958275-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5973191-A | AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE | VANDERBILT UNIVERSITY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998029382-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1998-07-09 | — | — | WO | disclosed |