Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK2 | O00142 | 4/20 | 0.60 |
| ▸ | TYMP | P19971 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | PYGM | P11217 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712041 | 1.00 | TK2 (0.60) | TK2TYMPSLC2A1PYGM | |
| SCHEMBL7190817 | 0.89 | TK2 (0.60) | TK2TYMPPYGM | |
| SCHEMBL3445234 | 0.89 | TK2 (0.60) | TK2TYMPPYGM | |
| SCHEMBL7190811 | 0.89 | TK2 (0.60) | TK2TYMPPYGM | |
| SCHEMBL3445235 | 0.89 | TK2 (0.60) | TK2TYMPPYGM | |
| SCHEMBL6362492 | 0.87 | TK2 (0.63) | TK2TYMPPYGM | |
| SCHEMBL24229243 | 0.87 | TK2 (0.67) | TK2TYMPPYGM | |
| SCHEMBL5502489 | 0.87 | TK2 (0.67) | TK2TYMPPYGM | |
| SCHEMBL5502493 | 0.87 | TK2 (0.67) | TK2TYMPPYGM | |
| SCHEMBL10267691 | 0.87 | TK2 (0.67) | TK2TYMPPYGM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121455-A4 | ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS INC (US) | 2004-03-24 | — | — | EP | disclosed |
| US-6365379-B1 | SELECTIVELY CLEAVING SINGLE STRANDED RNA BY CONTACTING WITH DIMERIZED ZINC FINGER PEPTIDE OF DEFINED AMINO ACID SEQUENCE IN ABSENSE OF ZINC | ISIS PHARMACEUTICALS, INC. | 2002-04-02 | — | — | US | disclosed |
| EP-1121455-A1 | ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000020622-A9 | ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS INC (US) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000020622-A1 | ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 2000-04-13 | — | — | WO | disclosed |