Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.50 |
| ▸ | FLT1 | P17948 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800248 | 0.85 | AR (0.50) | ARFLT1KDRALDH1A1HTT | |
| SCHEMBL6066143 | 0.81 | AR (0.50) | ARLMNA | |
| Hydrochloric Acid SCHEMBL27687289 | 0.80 | AR (0.49) | ARLMNA | |
| SCHEMBL30750830 | 0.79 | RAPGEF4 (0.40) | ARFLT1KDRHTTLMNA | |
| SCHEMBL6535264 | 0.79 | AR (0.46) | ARFLT1KDRHTTLMNA | |
| SCHEMBL3269568 | 0.78 | AR (0.50) | ARLMNA | |
| SCHEMBL11344645 | 0.77 | POLB (0.36) | ARFLT1KDRALDH1A1HTT | |
| SCHEMBL11935653 | 0.77 | ALDH1A1 (0.46) | ARFLT1KDRALDH1A1 | |
| SCHEMBL12895720 | 0.76 | MAPT (0.49) | ARHTTLMNAMAPT | |
| SCHEMBL30979605 | 0.76 | FFAR4 (0.52) | ARLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1207874-A4 | METHODS OF TREATING PROLIFERATIVE DISORDERS | BIOMEDICINES INC (US) | 2004-02-11 | — | — | EP | disclosed |
| US-6566395-B1 | Therapy of proliferative disorders, such as cancers, blood vessel disorders and fibrotic disorders by administering N-(3-methyl-4- trifluoromethylphenyl) 2-cyano-2-(cycloalkylcarbonyl)acetamide compounds | BIOMEDICINES, INC. | 2003-05-20 | — | — | US | disclosed |
| EP-1207874-A1 | METHODS OF TREATING PROLIFERATIVE DISORDERS | Biomedicines, Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2000071113-A1 | METHODS OF TREATING PROLIFERATIVE DISORDERS | BIOMEDICINES, INC. (US) | 2000-11-30 | — | — | WO | disclosed |