SCHEMBL6535573

SCHEMBL6535573

Cc1c[nH]c(=O)c(-c2ccc3ccccc3c2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 1/20 0.53
HDAC4 P56524 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
PDGFRB P09619 1/20 0.44
CTRC Q99895 1/20 0.41
CYP2A6 P11509 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
DAO P14920 1/20 0.41
MAOB P27338 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3774319 0.81 PARP1 (0.53) DAOALDH1A1HPGDPDE3BPDE3A
SCHEMBL6141487 0.79 DAO (0.48) DAOMAOBALDH1A1CBLCBLB
SCHEMBL6535851 0.75 ALKBH3 (0.46) PDGFRBTDP1DAOMAOBALDH1A1
SCHEMBL16652148 0.75 ALDH1A1 (0.64) GSTP1HDAC4HDAC2HDAC8PDGFRB
SCHEMBL11685438 0.75 MCL1 (0.45) PDGFRBDAOALDH1A1TSHRNOTUM
SCHEMBL28664983 0.75 GSTP1 (0.58) GSTP1HDAC4HDAC2HDAC8SLC6A2
SCHEMBL6535782 0.74 MCL1 (0.50) PDGFRBDAOMAOB
SCHEMBL6535526 0.74 AR (0.54) ALDH1A1CYP1A2SMN1; SMN2
SCHEMBL28412017 0.73 GSTP1 (0.51) GSTP1HDAC4HDAC2HDAC8PDGFRB
SCHEMBL4522255 0.73 GSTP1 (0.60) GSTP1HDAC4HDAC2HDAC8TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1261338-A4 COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY CYMAR INC (US) 2004-05-06 EP disclosed
EP-1261338-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY Cymar, Inc. (US) 2002-12-04 EP disclosed
WO-2001062253-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY CYMAR, INC. (US) 2001-08-30 WO disclosed