Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.66 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.63 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535715 | 1.00 | LTA4H (0.66) | LTA4HCHRNA3CHRNB4 | |
| SCHEMBL14293708 | 1.00 | LTA4H (0.66) | LTA4HCHRNA3CHRNB4 | |
| SCHEMBL6535790 | 0.87 | LTA4H (0.66) | LTA4HCHRNA3 | |
| SCHEMBL6535788 | 0.87 | LTA4H (0.66) | LTA4HCHRNA3 | |
| SCHEMBL10326507 | 0.87 | LTA4H (0.66) | LTA4HCHRNA3 | |
| SCHEMBL13809309 | 0.84 | LTA4H (0.69) | LTA4HCHRNA3 | |
| SCHEMBL11457974 | 0.84 | CHRNB4 (0.49) | LTA4HCHRNA3CHRNB4 | |
| SCHEMBL15300994 | 0.83 | LTA4H (0.66) | LTA4HCHRNA3 | |
| SCHEMBL2202052 | 0.83 | LTA4H (0.91) | LTA4HCHRNA3 | |
| SCHEMBL14541911 | 0.83 | CHRNA3 (0.68) | LTA4HCHRNA3CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242081-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1242081-A1 | CASPASES AND APOPTOSIS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6403792-B1 | INHIBIT PRODUCTION OF CASPASE 3 AND 7 IN MAMMALS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| WO-2001022966-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-05 | — | — | WO | disclosed |