Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | FTO | Q9C0B1 | 10/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6037012 | 0.86 | ALDH1A1 (0.56) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL601176 | 0.85 | FTO (0.59) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL5052755 | 0.82 | FTO (0.63) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL4576798 | 0.81 | FTO (0.58) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL6000384 | 0.81 | FTO (0.55) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL7907421 | 0.81 | ALDH1A1 (0.53) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL213292 | 0.81 | HPGD (0.53) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL2989053 | 0.81 | HPGD (0.53) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL223352 | 0.81 | HPGD (0.50) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL20832 | 0.80 | ALDH1A1 (0.60) | HPGDALDH1A1ALOX12CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040106109-A1 | Detection of ras mutations | BELLY ROBERT T (US) | 2004-06-03 | — | — | US | disclosed |
| EP-1412512-A4 | DETECTION OF RAS MUTATIONS | ORTHO CLINICAL DIAGNOSTICS INC (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-1412512-A2 | DETECTION OF RAS MUTATIONS | Ortho-Clinical Diagnostics, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002029005-A2 | DETECTION OF RAS MUTATIONS | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2002-04-11 | — | — | WO | disclosed |