Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28635052 | 0.87 | ERN1 (0.47) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30313760 | 0.83 | ERN1 (0.40) | ERN1RAB9AALDH1A1LCKGLA | |
| SCHEMBL6535983 | 0.82 | ERN1 (0.45) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29672073 | 0.82 | ERN1 (0.45) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12766888 | 0.82 | ERN1 (0.73) | ERN1NPC1RAB9AMAPTPTPRF | |
| SCHEMBL30564540 | 0.81 | NPC1 (0.46) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4980705 | 0.80 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL9754385 | 0.79 | ERN1 (0.45) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4579619 | 0.78 | HDAC4 (0.53) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29788008 | 0.78 | HDAC4 (0.53) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805674-B | Polymeric phosphine ligands, transition metal complexes comprising same, preparation and use thereof | 中国科学院上海有机化学研究所 | 2023-08-11 | — | — | CN | disclosed |
| CN-114805674-A | Polymeric phosphine ligands, transition metal complexes comprising same, preparation and use thereof | 中国科学院上海有机化学研究所 | 2022-07-29 | — | — | CN | disclosed |
| CN-112961041-B | Catechol compound and preparation method and application thereof | 心远(广州)药物研究有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-112961041-A | Catechol compound and preparation method and application thereof | 心远(广州)药物研究有限公司 | 2021-06-15 | — | — | CN | disclosed |
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |