Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6536016 | 0.80 | ERN1 (0.50) | NPC1SMN1; SMN2NFE2L2RAB9ATUBB4A | |
| SCHEMBL29788008 | 0.75 | HDAC4 (0.53) | NPC1SMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL4579619 | 0.75 | HDAC4 (0.53) | NPC1SMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL27397264 | 0.72 | NPC1 (0.46) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL3643547 | 0.72 | NPC1 (0.54) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL28081752 | 0.72 | ALOX5AP (0.48) | NPC1SMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL29814564 | 0.70 | PDE4B (0.60) | NPC1SMN1; SMN2RAB9AALDH1A1HTT | |
| SCHEMBL29814561 | 0.70 | PDE4B (0.60) | NPC1SMN1; SMN2RAB9AALDH1A1HTT | |
| SCHEMBL16055930 | 0.70 | ALDH1A1 (0.46) | NPC1SMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL8898516 | 0.70 | NPC1 (0.45) | NPC1SMN1; SMN2RAB9AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1965785-A1 | COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR | N.V. Organon (NL) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071638-A1 | COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR | N.V. ORGANON (NL) | 2007-06-28 | — | — | WO | disclosed |