Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263230 | 0.89 | HPGD (0.58) | SMN1; SMN2HPGDLMNACYP1A2PGR | |
| SCHEMBL10442500 | 0.88 | HPGD (0.56) | SMN1; SMN2HPGDLMNACYP1A2PGR | |
| SCHEMBL29853676 | 0.87 | SMN1; SMN2 (0.79) | SMN1; SMN2HPGDLMNACYP1A2CYP2C19 | |
| SCHEMBL7267474 | 0.87 | SMN1; SMN2 (0.79) | SMN1; SMN2HPGDLMNACYP1A2CYP2C19 | |
| Formaldehyde SCHEMBL29266746 | 0.86 | HPGD (0.55) | SMN1; SMN2HPGDLMNACYP1A2PGR | |
| SCHEMBL28036196 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EALDH1A1RAB9APOLB | |
| SCHEMBL31612942 | 0.83 | LMNA (0.56) | SMN1; SMN2HPGDLMNACYP1A2PGR | |
| SCHEMBL5342329 | 0.82 | SMN1; SMN2 (0.84) | SMN1; SMN2HPGDLMNACYP1A2CYP2C19 | |
| Formaldehyde SCHEMBL27994586 | 0.82 | HPGD (0.56) | SMN1; SMN2HPGDLMNACYP1A2PGR | |
| SCHEMBL14397805 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2HPGDCYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |