Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6536248 | 0.82 | CA1 (0.33) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6535991 | 0.81 | KDM4E (0.33) | KDM4EALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6536173 | 0.81 | KDM4E (0.33) | KDM4EALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6536124 | 0.79 | KDM4E (0.32) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6536233 | 0.78 | ADORA3 (0.32) | ALDH1A1 | |
| SCHEMBL9558947 | 0.58 | KDM1A (0.34) | MEN1KMT2AMAPTCYP3A4 | |
| SCHEMBL4752286 | 0.55 | POLB (0.31) | — | |
| SCHEMBL8782024 | 0.54 | TSHR (0.35) | LMNAMEN1KMT2ACYP3A4HSD17B10 | |
| SCHEMBL23393891 | 0.54 | CHRNA7 (0.44) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL8734945 | 0.53 | MAPT (0.34) | KDM4EALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |