Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3161543 | 0.95 | SMN1; SMN2 (0.34) | MEN1KMT2ASMN1; SMN2CYP19A1CYP2C9 | |
| SCHEMBL3170160 | 0.91 | — | — | |
| SCHEMBL5757984 | 0.81 | NPC1 (0.32) | SMN1; SMN2 | |
| SCHEMBL3168750 | 0.78 | HRH3 (0.32) | KCNA3HSD17B10 | |
| SCHEMBL6536730 | 0.75 | MEN1 (0.30) | MEN1KMT2ALMNANPSR1HSD17B10 | |
| SCHEMBL9127869 | 0.75 | CYP3A4 (0.41) | SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL9127864 | 0.75 | CYP3A4 (0.41) | SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL12869123 | 0.74 | LMNA (0.49) | MEN1KMT2ASMN1; SMN2CYP19A1CYP2C9 | |
| SCHEMBL917160 | 0.74 | HRH1 (0.37) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15459055 | 0.74 | MEN1 (0.46) | MEN1KMT2ASMN1; SMN2CYP19A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326605-A4 | METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS | UNIV CREIGHTON (US) | 2004-03-17 | — | — | EP | disclosed |
| EP-1326605-A1 | METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS | CREIGHTON UNIVERSITY (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2001085166-A1 | METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS | CREIGHTON UNIVERSITY (US) | 2001-11-15 | — | — | WO | disclosed |