Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | BHMT | Q93088 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280524 | 0.95 | LMNA (0.65) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL7692824 | 0.92 | TSHR (0.67) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL10567294 | 0.92 | LMNA (0.78) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL5168540 | 0.92 | TSHR (0.67) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL9110967 | 0.92 | TSHR (0.67) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL5168783 | 0.92 | TSHR (0.67) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL7693275 | 0.92 | TSHR (0.67) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL6866613 | 0.92 | LMNA (0.78) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL20475058 | 0.92 | TSHR (0.67) | LMNATDP1KMT2AHSD17B10BHMT | |
| SCHEMBL2353247 | 0.92 | TSHR (0.67) | LMNATDP1KMT2AHSD17B10BHMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326605-A4 | METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS | UNIV CREIGHTON (US) | 2004-03-17 | — | — | EP | disclosed |
| EP-1326605-A1 | METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS | CREIGHTON UNIVERSITY (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2001085166-A1 | METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS | CREIGHTON UNIVERSITY (US) | 2001-11-15 | — | — | WO | disclosed |