Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP6 | P51161 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 5/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652927 | 0.81 | GRM2 (0.43) | FUCA1GRM2GRM3HSD17B10NPSR1 | |
| SCHEMBL4106856 | 0.77 | CCR5 (0.41) | — | |
| SCHEMBL16053196 | 0.76 | KDM4E (0.31) | ALDH1A1TSHR | |
| SCHEMBL28833842 | 0.76 | CTSK (0.44) | ALDH1A1TSHR | |
| SCHEMBL23415559 | 0.76 | CTSK (0.44) | ALDH1A1TSHR | |
| SCHEMBL3666587 | 0.74 | FUCA1 (0.46) | FUCA1GRM2GRM3HSD17B10NPSR1 | |
| SCHEMBL6102343 | 0.74 | FUCA1 (0.46) | FUCA1GRM2GRM3HSD17B10NPSR1 | |
| SCHEMBL3833535 | 0.74 | FUCA1 (0.46) | FUCA1GRM2GRM3HSD17B10NPSR1 | |
| SCHEMBL743896 | 0.74 | FUCA1 (0.46) | FUCA1GRM2GRM3HSD17B10NPSR1 | |
| SCHEMBL16656041 | 0.73 | GRM2 (0.43) | FUCA1GRM2GRM3HSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |