SCHEMBL6537473

SCHEMBL6537473

CCOC(=O)COc1ccnc2c(N)cccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.48
F9 P00740 1/20 0.46
CHEK1 O14757 1/20 0.45
CASP3 P42574 1/20 0.45
CASP7 P55210 1/20 0.45
CASP9 P55211 1/20 0.45
ALDH1A1 P00352 4/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
USP2 O75604 1/20 0.42
HPGD P15428 3/20 0.42
HSD17B10 Q99714 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
MEN1 O00255 1/20 0.42
CASP1 P29466 1/20 0.42
KMT2A Q03164 1/20 0.42
ADORA2A P29274 1/20 0.41
ADORA1 P30542 1/20 0.41
TP53 P04637 1/20 0.41
HTT P42858 1/20 0.41
ABCB1 P08183 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12474991 0.82 ALDH1A1 (0.50) KDM4ECASP3ALDH1A1SMN1; SMN2HPGD
SCHEMBL6537658 0.81 ALDH1A1 (0.49) KDM4ECASP3CASP7CASP9ALDH1A1
SCHEMBL6537469 0.81 CHEK1 (0.52) KDM4ECHEK1ALDH1A1SMN1; SMN2HPGD
SCHEMBL5538129 0.79 KDM4E (0.53) KDM4EF9CASP3CASP7CASP9
SCHEMBL20150488 0.76 ALDH1A1 (0.59) KDM4EF9CASP3CASP7CASP9
SCHEMBL6537386 0.76 MAPT (0.51) KDM4EF9ALDH1A1SMN1; SMN2HPGD
SCHEMBL6992194 0.75 KDM4E (0.52) KDM4EF9CASP3CASP7CASP9
SCHEMBL31520212 0.74 TSHR (0.67) KDM4EF9CASP3CASP7CASP9
SCHEMBL11490448 0.74 TSHR (0.67) KDM4EF9CASP3CASP7CASP9
SCHEMBL15818384 0.73 MAPT (0.60) KDM4ECASP7ALDH1A1SMN1; SMN2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876345-B1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO (JP) 2004-08-18 EP disclosed
US-6008230-A TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0876345-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-11 EP disclosed
WO-1997014681-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-04-24 WO disclosed