Sugi Predict

Sugi Predict / Compounds / SCHEMBL11490448

SCHEMBL11490448

SCHEMBL11490448

CCOC(=O)COc1cccc2ccccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.67
▸ ALDH1A1 P00352 5/20 0.64
▸ HPGD P15428 5/20 0.64
▸ KDM4E B2RXH2 4/20 0.64
▸ TDP1 Q9NUW8 1/20 0.64
▸ OGG1 O15527 1/20 0.57
▸ LMNA P02545 2/20 0.57
▸ MAPT P10636 2/20 0.57
▸ MAPK1 P28482 2/20 0.57
▸ NPSR1 Q6W5P4 2/20 0.57
▸ TLR9 Q9NR96 2/20 0.57
▸ MITF O75030 1/20 0.57
▸ HSP90AA1 P07900 1/20 0.57
▸ PKM P14618 1/20 0.57
▸ F9 P00740 1/20 0.56
▸ USP2 O75604 1/20 0.56
▸ CASP3 P42574 1/20 0.56
▸ CASP7 P55210 1/20 0.56
▸ CASP9 P55211 1/20 0.56
▸ ABCB1 P08183 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31520212 1.00 TSHR (0.67) TSHRALDH1A1HPGDKDM4ETDP1
SCHEMBL22534435 0.87 F9 (0.53) TSHRALDH1A1HPGDKDM4ETDP1
SCHEMBL28306542 0.85 TSHR (0.63) TSHRALDH1A1HPGDKDM4ETDP1
SCHEMBL9439384 0.85 KDM4E (0.56) TSHRALDH1A1HPGDKDM4ETDP1
SCHEMBL29485630 0.85 ALDH1A1 (0.61) TSHRALDH1A1HPGDKDM4ELMNA
SCHEMBL22610045 0.85 ALDH1A1 (0.61) TSHRALDH1A1HPGDKDM4ELMNA
SCHEMBL2010417 0.85 USP2 (0.67) ALDH1A1HPGDKDM4ELMNAMAPT
SCHEMBL8754853 0.84 USP2 (0.56) TSHRALDH1A1HPGDKDM4ELMNA
SCHEMBL5162627 0.84 ALDH1A1 (0.68) TSHRALDH1A1HPGDKDM4ETDP1
SCHEMBL6999173 0.83 PDE10A (0.50) TSHRALDH1A1KDM4EMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119776927-B Tin-silver alloy electroplating solution and preparation method and application thereof 深圳市联合蓝海应用材料科技股份有限公司 2025-06-24 — — CN disclosed
CN-119776927-A Tin-silver alloy electroplating solution and preparation method and application thereof 深圳市联合蓝海应用材料科技股份有限公司 2025-04-08 — — CN disclosed
US-20190083482-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2019-03-21 — — US disclosed
US-20190083482-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2019-03-21 — — US disclosed
CN-106146450-B Formoononetin derivative, preparation method and medical usage 南京华迈生物医药科技有限公司 2019-02-15 — — CN disclosed
EP-3406607-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2018-11-28 — — EP disclosed
US-20180162847-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2018-06-14 — — US disclosed
US-20180162847-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2018-06-14 — — US disclosed
US-20180162847-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2018-06-14 — — US disclosed
EP-2935243-B1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF EPIZYME INC (US) 2018-03-14 — — EP disclosed
US-20150191432-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2015-07-09 — — US disclosed
CN-104672192-A Derivatives of isoflavones amides, as well as preparation method and medical application of derivatives UNIV CHINA PHARMA 2015-06-03 — — CN disclosed
US-8940726-B2 PRMT5 inhibitors and uses thereof Epizyme, Inc. (US) 2015-01-27 — — US disclosed
US-8940726-B2 PRMT5 inhibitors and uses thereof Epizyme, Inc. (US) 2015-01-27 — — US disclosed
US-8940726-B2 PRMT5 inhibitors and uses thereof Epizyme, Inc. (US) 2015-01-27 — — US disclosed
CN-104276974-A N-Acetylglucosamine-1-phosphate uridyltransferase inhibitor as well as preparation method and application thereof UNIV HUAZHONG AGRICULTURAL 2015-01-14 — — CN disclosed
US-20140221345-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-08-07 — — US disclosed
WO-2014100730-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2014-06-26 — — WO disclosed
WO-2014100730-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2014-06-26 — — WO disclosed
US-4195093-A DIURETIC AND URICOSURIC AGENTS ALBERT ROLLAND S.A. (FR) 1980-03-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150191432-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT6 TSHR 3498/4885ALDH1A1 2460/4885HPGD 2677/4885
US-20140221345-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT6 TSHR 3498/4885ALDH1A1 2460/4885HPGD 2677/4885
US-20190083482-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT6 TSHR 3498/4885ALDH1A1 2460/4885HPGD 2677/4885
US-20180162847-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF PRMT5, PRMT1, PRMT3 TSHR 3733/4885ALDH1A1 2705/4885HPGD 2275/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.