SCHEMBL6537488

SCHEMBL6537488

O=C(Nc1cccc2c(-n3ccnc3)ccnc12)c1c(Cl)cccc1Cl

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.48
CYP1A2 P05177 2/20 0.48
CYP2D6 P10635 2/20 0.48
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
ATR Q13535 2/20 0.46
JAK2 O60674 3/20 0.46
TYK2 P29597 3/20 0.46
JAK1 P23458 2/20 0.46
CD38 P28907 7/20 0.44
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
KDR P35968 1/20 0.41
CRHBP P24387 1/20 0.40
HTT P42858 1/20 0.40
CRHR2 Q13324 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CGAS Q8N884 1/20 0.39
MCL1 Q07820 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6537403 0.89 CD38 (0.45) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6537494 0.87 CD38 (0.46) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6538101 0.87 CYP3A4 (0.46) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6537819 0.86 CYP3A4 (0.45) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6537639 0.85 CD38 (0.46) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6538007 0.83 CYP3A4 (0.43) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6537943 0.83 CYP3A4 (0.47) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6537723 0.82 JAK2 (0.45) CYP3A4JAK2TYK2JAK1MEN1
SCHEMBL6537900 0.81 ICAM1 (0.44) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6537421 0.81 TYK2 (0.46) CYP3A4ATRJAK2TYK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876345-B1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO (JP) 2004-08-18 EP disclosed
US-6008230-A TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0876345-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-11 EP disclosed
WO-1997014681-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-04-24 WO disclosed