Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 2/20 | 0.44 |
| ▸ | SELE | P16581 | 2/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.40 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8475365 | 0.83 | JAK2 (0.47) | CYP3A4LMNAMAPTKDRPDGFRA | |
| SCHEMBL6537488 | 0.81 | CYP3A4 (0.48) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6537597 | 0.76 | HSD17B10 (0.55) | LMNAMAPTKDRPDGFRAJAK2 | |
| SCHEMBL6537462 | 0.75 | TYK2 (0.49) | CYP3A4LMNAMAPTKDRJAK2 | |
| SCHEMBL8474859 | 0.74 | CYP3A4 (0.52) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6537504 | 0.74 | CYP3A4 (0.47) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6537346 | 0.74 | CYP3A4 (0.47) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6537494 | 0.74 | CD38 (0.46) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6537740 | 0.74 | CYP3A4 (0.46) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6538283 | 0.74 | CYP3A4 (0.46) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |