Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537941 | 0.86 | CSF1R (0.49) | MAPK10MAPK8LCKMAPK14ATR | |
| SCHEMBL6538059 | 0.85 | LCK (0.47) | MAPK10MAPK8LCKMAPK14ATR | |
| SCHEMBL6537773 | 0.82 | LMNA (0.64) | MAPK10MAPK1KDM4EMEN1KMT2A | |
| SCHEMBL6537933 | 0.80 | TYK2 (0.44) | TSHRMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6537962 | 0.79 | TYK2 (0.46) | MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6537417 | 0.79 | TYK2 (0.40) | ATRTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6537346 | 0.78 | CYP3A4 (0.47) | ATRMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6537716 | 0.77 | HSD17B10 (0.52) | LCKMAPK14MAPK1TSHRKDM4E | |
| SCHEMBL8489798 | 0.77 | KDM4E (0.46) | LCKMAPK14KDM4EMEN1KMT2A | |
| SCHEMBL8489794 | 0.76 | LCK (0.44) | MAPK10MAPK8LCKMAPK14ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |