Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Chloro-6,8-Difluoroquinoline SCHEMBL30225421 | 0.81 | CDK8 (0.43) | NR4A2MMP14KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL6537786 | 0.81 | NR4A2 (0.46) | NR4A2MMP14G6PDPIM1PIM3 | |
| 4-Chloro-6,8-Difluoroquinoline SCHEMBL264453 | 0.81 | CDK8 (0.43) | NR4A2MMP14KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL6537871 | 0.79 | NR4A2 (0.43) | NR4A2MMP14G6PDPIM1PIM3 | |
| SCHEMBL11545025 | 0.79 | CCR1 (0.48) | G6PDPIM1PIM3KDM4EHSP90AA1 | |
| SCHEMBL6537370 | 0.78 | SLC40A1 (0.44) | NR4A2MMP14G6PDPIM1PIM3 | |
| SCHEMBL24009363 | 0.75 | PDE2A (0.42) | G6PDKDM4EHSP90AA1TDP1MAPT | |
| SCHEMBL2270856 | 0.75 | HSP90AA1 (0.52) | NR4A2MMP14G6PDPIM1PIM3 | |
| SCHEMBL31399685 | 0.73 | NR4A2 (0.37) | NR4A2MMP14SOS2KDM4EALDH1A1 | |
| SCHEMBL6538436 | 0.72 | ALDH1A1 (0.61) | KDM4EALDH1A1HSP90AA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |