SCHEMBL6537982

SCHEMBL6537982

COCc1cnc2c(NC(=O)c3ccccc3C(F)(F)F)cccc2c1Cl

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGES O14684 19/20 0.51
RXFP1 Q9HBX9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6537426 0.84 PTGES (0.50) PTGESRXFP1
SCHEMBL6537987 0.84 PTGES (0.47) PTGESRXFP1
SCHEMBL6537358 0.83 KDM4E (0.50)
SCHEMBL6537695 0.83 PTGES (0.44) PTGES
SCHEMBL6537593 0.82 PTGES (0.46) PTGESRXFP1
SCHEMBL6537998 0.80 PTGES (0.45) PTGESRXFP1
SCHEMBL8486940 0.75 PTGES (0.45) PTGESRXFP1
SCHEMBL6537820 0.74 RXFP1 (0.45) PTGESRXFP1
SCHEMBL6538002 0.74 RXFP1 (0.45) PTGESRXFP1
SCHEMBL6537759 0.74 PTGES (0.44) PTGES

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876345-B1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO (JP) 2004-08-18 EP disclosed
US-6008230-A TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0876345-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-11 EP disclosed
WO-1997014681-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-04-24 WO disclosed