Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 16/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538197 | 0.87 | PTGES (0.43) | PTGESTP53MAPTNR1H2NR1H3 | |
| SCHEMBL6538307 | 0.84 | MEN1 (0.48) | — | |
| SCHEMBL6537982 | 0.84 | PTGES (0.51) | PTGESRXFP1 | |
| SCHEMBL6537831 | 0.83 | PTGES (0.40) | PTGES | |
| SCHEMBL6537593 | 0.77 | PTGES (0.46) | PTGESRXFP1 | |
| SCHEMBL8486940 | 0.77 | PTGES (0.45) | PTGESTP53MAPTRXFP1 | |
| SCHEMBL6537998 | 0.76 | PTGES (0.45) | PTGESTP53MAPTRXFP1 | |
| SCHEMBL6537719 | 0.74 | PTGES (0.40) | PTGES | |
| SCHEMBL6537820 | 0.74 | RXFP1 (0.45) | PTGESTP53MAPTRXFP1 | |
| SCHEMBL6538002 | 0.73 | RXFP1 (0.45) | PTGESTP53MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |