Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 7/20 | 0.49 |
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | FERMT2 | Q96AC1 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538110 | 0.93 | TYK2 (0.51) | SMN1; SMN2HTTHSD17B10TYK2JAK2 | |
| SCHEMBL6537677 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTHSD17B10TYK2JAK2 | |
| SCHEMBL6537338 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTHSD17B10TYK2JAK2 | |
| SCHEMBL6537898 | 0.84 | SMN1; SMN2 (0.70) | SMN1; SMN2HTTHSD17B10TYK2JAK2 | |
| SCHEMBL6537668 | 0.83 | TYK2 (0.55) | SMN1; SMN2HTTTYK2JAK2JAK1 | |
| SCHEMBL6537375 | 0.83 | CCNC (0.48) | SMN1; SMN2HTTHSD17B10TYK2JAK2 | |
| SCHEMBL6538261 | 0.83 | SLC40A1 (0.55) | SMN1; SMN2HTTHSD17B10TYK2JAK2 | |
| SCHEMBL6537556 | 0.83 | JAK2 (0.46) | SMN1; SMN2HTTHSD17B10TYK2JAK2 | |
| SCHEMBL6538203 | 0.81 | TYK2 (0.55) | SMN1; SMN2HTTHSD17B10TYK2JAK2 | |
| SCHEMBL6538073 | 0.81 | TYK2 (0.56) | SMN1; SMN2HTTTYK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |