SCHEMBL6538176

SCHEMBL6538176

Cc1cnc2c(NC(=O)c3ccccc3[N+](=O)[O-])cccc2c1-n1ccnc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 2/20 0.45
HPGD P15428 1/20 0.45
GAA P10253 2/20 0.44
HTT P42858 2/20 0.44
NCOA1 Q15788 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
NCOA3 Q9Y6Q9 1/20 0.44
KMT2A Q03164 4/20 0.43
MEN1 O00255 3/20 0.43
CRHBP P24387 1/20 0.43
CRHR2 Q13324 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
RAB9A P51151 1/20 0.42
LMNA P02545 1/20 0.41
MAPT P10636 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6537717 0.87 MEN1 (0.45) KDM4EALDH1A1HPGDGAAHTT
Hydrochloric Acid SCHEMBL6537552 0.86 KDM4E (0.43) KDM4EALDH1A1GAAHTTNCOA1
SCHEMBL6537671 0.84 SMN1; SMN2 (0.47) KDM4EALDH1A1HPGDGAAHTT
SCHEMBL6538369 0.84 PTGES (0.44) KDM4EALDH1A1SMN1; SMN2KMT2AMEN1
SCHEMBL8474859 0.80 CYP3A4 (0.52) GAAHTTSMN1; SMN2KMT2AMEN1
SCHEMBL6537586 0.80 KDM4E (0.53) KDM4EALDH1A1HPGDKMT2AMEN1
SCHEMBL6537662 0.73 MEN1 (0.61) KDM4EALDH1A1HPGDGAAHTT
SCHEMBL6537644 0.72 CYP1A2 (0.51) KDM4EALDH1A1HPGDGAAHTT
SCHEMBL6537479 0.71 ALDH1A1 (0.49) KDM4EALDH1A1HPGDGAAHTT
SCHEMBL6537593 0.71 PTGES (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876345-B1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO (JP) 2004-08-18 EP disclosed
US-6008230-A TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0876345-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-11 EP disclosed
WO-1997014681-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-04-24 WO disclosed