Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538281 | 0.85 | CHEK1 (0.49) | CHEK1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL6537478 | 0.82 | MAPK1 (0.40) | SMN1; SMN2NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL6537389 | 0.77 | POLB (0.43) | SMN1; SMN2KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL6537469 | 0.76 | CHEK1 (0.52) | CHEK1SMN1; SMN2KMT2AKDM4ELMNA | |
| SCHEMBL6536546 | 0.76 | CHEK1 (0.52) | CHEK1SMN1; SMN2KMT2AALDH1A1MAPK1 | |
| SCHEMBL30774516 | 0.73 | SMN1; SMN2 (0.46) | CHEK1SMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL15864578 | 0.73 | SMN1; SMN2 (0.46) | CHEK1SMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL19474972 | 0.72 | L3MBTL1 (0.46) | CHEK1SMN1; SMN2KMT2AKDM4ELMNA | |
| SCHEMBL28118721 | 0.70 | CHEK1 (0.50) | CHEK1SMN1; SMN2KMT2AKDM4ELMNA | |
| SCHEMBL6537473 | 0.70 | KDM4E (0.48) | CHEK1SMN1; SMN2NPC1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |