Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.41 |
| ▸ | CPT1A | P50416 | 4/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 4/20 | 0.40 |
| ▸ | CPT2 | P23786 | 3/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6539147 | 1.00 | MAOB (0.49) | MAOBADRB3ADRB1CPT1ACPT1B | |
| SCHEMBL6539059 | 0.83 | ADRB3 (0.61) | MAOBADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL6539055 | 0.83 | ADRB3 (0.61) | MAOBADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL6539659 | 0.77 | ADRB3 (0.47) | ADRB3ADRB1ADRB2BACE1SMO | |
| SCHEMBL6539651 | 0.77 | ADRB3 (0.47) | ADRB3ADRB1ADRB2BACE1SMO | |
| SCHEMBL6539237 | 0.73 | BACE1 (0.52) | ADRB3ADRB1ADRB2BACE1SLC2A1 | |
| SCHEMBL6539232 | 0.73 | BACE1 (0.52) | ADRB3ADRB1ADRB2BACE1SLC2A1 | |
| SCHEMBL6540029 | 0.69 | BACE1 (0.53) | ADRB3ADRB1ADRB2BACE1KDM4E | |
| SCHEMBL6540024 | 0.69 | BACE1 (0.53) | ADRB3ADRB1ADRB2BACE1KDM4E | |
| SCHEMBL15887043 | 0.68 | MAOB (1.00) | MAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6826033-B2 | BETA 3 ADRENERGIC RECEPTOR AGONISTS; TREATMENT OF POLLAKIURIA, URINARY INCONTINENCE, OBESITY OR DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-20040037022-A1 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2004-02-26 | — | — | US | disclosed |