Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 11/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6539237 | 1.00 | BACE1 (0.52) | BACE1ADRB3ITGB1ITGA4ADRB1 | |
| SCHEMBL6540024 | 0.82 | BACE1 (0.53) | BACE1ADRB3ITGB1ITGA4ADRB1 | |
| SCHEMBL6540029 | 0.82 | BACE1 (0.53) | BACE1ADRB3ITGB1ITGA4ADRB1 | |
| SCHEMBL6538935 | 0.82 | BACE1 (0.54) | BACE1ADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL6539195 | 0.82 | BACE1 (0.54) | BACE1ADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL6538940 | 0.82 | BACE1 (0.54) | BACE1ADRB3ADRB1ADRB2SLC2A1 | |
| Hydrochloric Acid SCHEMBL6538854 | 0.77 | ADRB3 (0.68) | ADRB3ADRB1ADRB2SLC2A1GLA | |
| Hydrochloric Acid SCHEMBL6538857 | 0.77 | ADRB3 (0.68) | ADRB3ADRB1ADRB2SLC2A1GLA | |
| SCHEMBL6478726 | 0.76 | BACE1 (0.52) | BACE1ADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL6478721 | 0.76 | BACE1 (0.52) | BACE1ADRB3ADRB1ADRB2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6826033-B2 | BETA 3 ADRENERGIC RECEPTOR AGONISTS; TREATMENT OF POLLAKIURIA, URINARY INCONTINENCE, OBESITY OR DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-20040037022-A1 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2004-02-26 | — | — | US | disclosed |
| WO-2002024635-A2 | AMINOALCOHOL DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-28 | — | — | WO | disclosed |