Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 5/20 | 0.50 |
| ▸ | CA9 | Q16790 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL96264 | 0.90 | CA12 (0.46) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL3428767 | 0.89 | ALDH1A1 (0.45) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL3428766 | 0.87 | ALDH1A1 (0.44) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL542744 | 0.84 | CA12 (0.54) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL14023314 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL9432852 | 0.82 | CA12 (0.46) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL8002985 | 0.80 | CA12 (0.48) | ALDH1A1CA12CA9CA2CA1 | |
| SCHEMBL5543867 | 0.80 | CA12 (0.48) | ALDH1A1CA12CA9CA2CA1 | |
| SCHEMBL10352190 | 0.80 | CA12 (0.48) | ALDH1A1CA12CA9CA2CA1 | |
| SCHEMBL22907476 | 0.80 | CA12 (0.48) | ALDH1A1CA12CA9CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137468-B1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2021-10-06 | — | — | EP | disclosed |
| US-10844068-B2 | Compounds and compositions as toll-like receptor 7 agonists | NOVARTIS AG (CH) | 2020-11-24 | — | — | US | disclosed |
| US-20190345166-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION | 2019-11-14 | — | — | US | disclosed |
| US-10407431-B2 | Compounds and compositions as toll-like receptor 7 agonists | NOVARTIS AG (CH) | 2019-09-10 | — | — | US | disclosed |
| US-20180186802-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION | 2018-07-05 | — | — | US | disclosed |
| US-9944649-B2 | Compounds and compositions as toll-like receptor 7 agonists | NOVARTIS AG (CH) | 2018-04-17 | — | — | US | disclosed |
| EP-3137468-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | Novartis AG (CH) | 2017-03-08 | — | — | EP | disclosed |
| US-20170044168-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2017-02-16 | — | — | US | disclosed |
| EP-2242359-B1 | SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS | UNIV STRASBOURG (FR) | 2016-06-01 | — | — | EP | disclosed |
| WO-2015168279-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2015-11-05 | — | — | WO | disclosed |
| EP-1255748-A1 | BETA-ALANINE DERIVATIVES AND THEIR USE AS RECEPTOR ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060813-A1 | BETA-ALANINE DERIVATIVES AND THEIR USE AS RECEPTOR ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-08-23 | — | — | WO | disclosed |
| US-5972946-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0826673-A1 | ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-03-04 | — | — | EP | disclosed |
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0118743-B1 | CURABLE COMPOSITIONS CONTAINING URETHANES,AND THE USE OF THE COMPOSITIONS IN ELECTRODEPOSITION | PPG INDUSTRIES, INC. (US) | 1987-06-16 | — | — | EP | disclosed |
| EP-0118743-A1 | Curable compositions containing urethanes,and the use of the compositions in electrodeposition | PPG INDUSTRIES, INC. (US) | 1984-09-19 | — | — | EP | disclosed |
| US-4452963-A | CATIONIC POLYMER COATING COMPOSITIONS | PPG INDUSTRIES, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4452930-A | FOR LOW TEMPERATURE CURING OF CATIONIC POLYMERS | PPG INDUSTRIES, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4452681-A | LOW TEMPERATURE CURING OF WATER-DISPERSED CATIONIC POLYMERS | PPG INDUSTRIES, INC. (US) | 1984-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407431-B2 | Compounds and compositions as toll-like receptor 7 agonists | TLR7, TLR3, TLR1 | ALDH1A1 3512/4885HPGD 1739/4885CA12 3977/4885 |
| US-20180186802-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | TLR7, TLR3, TLR1 | ALDH1A1 3512/4885HPGD 1739/4885CA12 3977/4885 |
| US-10844068-B2 | Compounds and compositions as toll-like receptor 7 agonists | TLR7, TLR3, TLR1 | ALDH1A1 3512/4885HPGD 1739/4885CA12 3977/4885 |
| US-20190345166-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | TLR7, TLR3, TLR1 | ALDH1A1 3512/4885HPGD 1739/4885CA12 3977/4885 |
| US-20170044168-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | TLR7, TLR3, TLR1 | ALDH1A1 4263/4885HPGD 2381/4885CA12 4262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.