Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246399 | 0.83 | HTR3E (0.49) | MEN1KMT2AGRM4KDRHTR3E | |
| SCHEMBL1525499 | 0.78 | HTR3E (0.44) | RAB9AMEN1KMT2AGRM4KDR | |
| SCHEMBL30019653 | 0.78 | HTR3E (0.44) | RAB9AMEN1KMT2AGRM4KDR | |
| SCHEMBL28217604 | 0.76 | GRM4 (0.44) | MEN1KMT2AGRM4KDRHTR3E | |
| SCHEMBL27734542 | 0.76 | HTR3E (0.43) | MEN1KMT2AGRM4KDRHTR3E | |
| SCHEMBL1513809 | 0.76 | HTR3E (0.43) | MEN1KMT2AGRM4KITKDR | |
| SCHEMBL6308840 | 0.74 | KDR (0.67) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL1513968 | 0.74 | NPFFR2 (0.43) | GRM4KDRHTR3EHTR3BHTR3A | |
| SCHEMBL27702049 | 0.74 | HTR3E (0.41) | GRM4KDRHTR3EHTR3BHTR3A | |
| SCHEMBL6385546 | 0.72 | KDR (0.52) | KITKDRFLT1NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465623-A1 | UREA DERIVATIVES | Bayer HealthCare AG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003055484-A1 | UREA DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-07-10 | — | — | WO | disclosed |