SCHEMBL6541546

SCHEMBL6541546

O=C(O)c1ccc2c(c1Cl)C(=O)OC2=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYMS P04818 2/20 0.51
TSHR P16473 3/20 0.44
CA12 O43570 4/20 0.43
CA7 P43166 4/20 0.43
CA1 P00915 3/20 0.43
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43
CA4 P22748 2/20 0.39
ALDH1A1 P00352 7/20 0.39
MAPT P10636 4/20 0.39
MAPK1 P28482 2/20 0.39
LMNA P02545 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
POLB P06746 1/20 0.39
THRB P10828 1/20 0.39
RECQL P46063 1/20 0.39
CYP3A4 P08684 1/20 0.38
FTO Q9C0B1 1/20 0.37
TTR P02766 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5671377 0.86 TYMS (0.51) TYMSTSHRCA12CA7CA1
SCHEMBL2434561 0.80 TYMS (0.53) TYMSCA12CA7CA1CA2
SCHEMBL26123957 0.79 TYMS (0.56) TYMSTSHRCA12CA7CA1
SCHEMBL27658123 0.79 TYMS (0.51) TYMSTSHRCA12CA7CA1
SCHEMBL705878 0.79 CYP3A4 (0.46) TYMSTSHRCA12CA7CA1
SCHEMBL25187023 0.79 TYMS (0.51) TYMSTSHRCA12CA7CA1
SCHEMBL30059704 0.77 TYMS (0.50) TYMSCA12CA7CA1CA2
SCHEMBL27922461 0.77 TYMS (0.50) TYMSTSHRCA12CA7CA1
SCHEMBL29603070 0.76 TYMS (0.50) TYMSTSHRCA12CA7CA1
SCHEMBL15757935 0.76 TYMS (0.50) TYMSTSHRCA12CA7CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5760101-A AN OLIGOMERIC CONDENSATION PRODUCT OR A POLYESTERS ADHESIVE FOR TEETH FILLING HERAEUS KULZER GMBH (DE) 1998-06-02 US claimed
CN-110114389-B Emulsion of nitrogen atom-containing polymer or salt thereof, method for producing same, and method for producing particles 富士胶片株式会社 2022-04-01 CN disclosed
CN-1976996-B Miscible polyimide blends SABIC INNOVATIVE PLASTICS IP 2012-10-10 CN disclosed
CN-100379792-C Process for manufacture of functionalized polyphenylene ethers GEN ELECTRIC (US) 2008-04-09 CN disclosed
CN-1976996-A Miscible polyimide blends GEN ELECTRIC (US) 2007-06-06 CN disclosed
CN-1314738-C Conductive polyphenylene ether-polyamide compositions, methods of making the same, and articles therefrom GEN ELECTRIC (US) 2007-05-09 CN disclosed
CN-1606590-A Conductive polyphenylene ether-polyamide compositions, methods of making the same, and articles therefrom GEN ELECTRIC (US) 2005-04-13 CN disclosed
EP-1477475-A1 Compounds for use as a medicine increasing the contractility of a heart, a heart muscle or cells of a heart muscle Procorde GmbH (DE) 2004-11-17 EP disclosed
CN-1334838-A Process for the preparation of functionalized polyphenylene ethers GEN ELECTRIC (US) 2002-02-06 CN disclosed
US-6069227-A UNSATURATED POLYESTER HOMOPOLYMERS OF AN AROMATIC TRI- OR TETRA-CARBOXYLIC ACIDS AND DIHYDROXYALKYL (METH)ACRYLATES; MUCH IMPROVED ADHESION TO PLASTIC SURFACES, ESPECIALLY POLYCARBONATES; WEATHERPROOFING; OPTICS; MECHANICAL PROPERTIES BAYER A.G. (DE) 2000-05-30 US disclosed
US-5808104-A DENTAL FILLINGS WITH HIGH BONDING STRENGTH HERAEUS KULZER GMBH (DE) 1998-09-15 US disclosed
US-5760101-A AN OLIGOMERIC CONDENSATION PRODUCT OR A POLYESTERS ADHESIVE FOR TEETH FILLING HERAEUS KULZER GMBH (DE) 1998-06-02 US disclosed
US-5294646-A N-alkyl-n-(meth)acryloyloxyalkylcarboxamides of aromatic carboxylic acids and aromatic carboxylic acid anhydrides, and adhesives containing these compounds BAYER AKTIENGESELLSCHAFT (DE) 1994-03-15 US disclosed
US-5241081-A N-ALKYL-N-(METH)ACRYLOYLOXYALKYLCARBOXAMIDES OF AROMATIC CARBOXYLIC ACIDS AND AROMATIC CARBOXYLIC ACID ANHYDRIDES, AND ADHESIVES CONTAINING THESE COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1993-08-31 US disclosed
US-4952708-A REACTING SUBSTITUTED AROMATIC ACID HALIDES WITH SUBSTITUTED DI-OR POLYSILANES USING TRANSITION METAL COMPLEX AS CATALYST GENERAL ELECTRIC COMPANY (US) 1990-08-28 US disclosed
EP-0339455-A2 Process for preparing biaryl compounds GENERAL ELECTRIC COMPANY (US) 1989-11-02 EP disclosed
CN-87101247-A Elastomerics 1988-06-29 CN disclosed