Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CD44 | P16070 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9879909 | 0.87 | GABRA1 (0.39) | POLBLMNATRPA1SLC6A2HTR2B | |
| SCHEMBL9791485 | 0.86 | POLB (0.39) | POLBCD44LMNATRPA1SLC6A2 | |
| SCHEMBL19505690 | 0.81 | POLB (0.34) | POLBCD44LMNATRPA1SLC6A2 | |
| SCHEMBL6285831 | 0.79 | GABRA1 (0.48) | POLBLMNATRPA1SLC6A2HTR2B | |
| SCHEMBL29502173 | 0.78 | CD44 (0.52) | POLBCD44LMNASLC6A2HTR2B | |
| SCHEMBL399144 | 0.78 | CD44 (0.52) | POLBCD44LMNASLC6A2HTR2B | |
| SCHEMBL409314 | 0.78 | POLB (0.61) | POLBCD44LMNAALDH1A1GAA | |
| SCHEMBL19998489 | 0.77 | LMNA (0.38) | POLBLMNATRPA1SLC6A2HTR2B | |
| Hydrochloric Acid SCHEMBL2860371 | 0.76 | CD44 (0.50) | POLBCD44LMNASLC6A2HTR2B | |
| Hydrochloric Acid SCHEMBL8125648 | 0.74 | POLB (0.58) | POLBCD44LMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154976-B1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME (US) | 2019-07-24 | — | — | EP | disclosed |
| US-10100064-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME CORP. (US) | 2018-10-16 | — | — | US | disclosed |
| US-20170114078-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP DOHME CORP. (US) | 2017-04-27 | — | — | US | disclosed |
| EP-1149629-B1 | Hydrogenation of aromatic amines using lithium aluminate as the catalyst support | AIR PROD & CHEM (US) | 2004-06-09 | — | — | EP | disclosed |
| EP-1149629-A1 | Hydrogenation of aromatic amines using lithium aluminate as the catalyst support | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2001-10-31 | — | — | EP | disclosed |
| US-6184416-B1 | THE USE OF A RHODIUM CATALYST CARRIED ON A LITHIUM ALUMINATE (LIAL5O8) SUPPORT RING HYDROGENATE AROMATIC AMINES; CATALYST SELECTIVITY; REUSE OF THE CATALYST; CAN BE USED WITH ALKALI METAL REACTION PROMOTERS; LOW WATER SOLUBILITY; KINETICS | AIR PRODUCTS AND CHEMICALS, INC. | 2001-02-06 | — | — | US | disclosed |
| US-6140540-A | USING MIXTURE OF COBALT WITH RHODIUM, RUTHENIUM, PALLADIUM AND, OR PLATIMUM | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0781267-B1 | METHOD OF INCREASING HYDROGENATION RATE OF AROMATIC AMINES | ARCO CHEM TECH (US) | 2000-02-09 | — | — | EP | disclosed |
| EP-0946533-A1 | PROCESS FOR PREPARING 2,1,3-BENZOTHIADIAZOLES | BAYER AG (DE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027076-A1 | PROCESS FOR PREPARING 2,1,3-BENZOTHIADIAZOLES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | disclosed |
| US-5360934-A | Aluminum oxide supported rhodium catalyst | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0618188-A2 | Process for the preparation of cyclohexylamines by catalytic hydrogenation of anilines | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1994-10-05 | — | — | EP | disclosed |
| EP-0392435-B1 | HYDROGENATION OF AROMATIC AMINES USING RHODIUM ON TITANIA OR ZIRCONIA SUPPORT | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| EP-0335272-B1 | HYDROGENATION OF AROMATIC AMINES TO PRODUCE THEIR RING HYDROGENATED COUNTERPARTS | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1993-09-22 | — | — | EP | disclosed |
| WO-1993016030-A1 | PROMOTERS FOR HYDROGENATION OF AROMATIC AMINES | OLIN CORPORATION (US) | 1993-08-19 | — | — | WO | disclosed |
| US-5214212-A | Salt of transition or lanthanide metal as a promoter, reaction of methylenedianiline to produce corresponding cyclohexyl compound | OLIN CORPORATION (US) | 1993-05-25 | — | — | US | disclosed |
| US-5026914-A | Catalyst selectivity | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0392435-A1 | Hydrogenation of aromatic amines using rhodium on titania or zirconia support | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1990-10-17 | — | — | EP | disclosed |
| US-4960941-A | HYDROGENATION CATALYST OF RHODIUM ON TITANIA SUPPORT | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0335272-A2 | Hydrogenation of aromatic amines to produce their ring hydrogenated counterparts | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1989-10-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114078-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | POLB 277/4885CD44 4209/4885LMNA 3136/4885 |
| US-10100064-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3CA, PI4KA | POLB 277/4885CD44 4209/4885LMNA 3136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.