Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.69 |
| ▸ | CDK1 | P06493 | 9/20 | 0.61 |
| ▸ | KDR | P35968 | 8/20 | 0.61 |
| ▸ | CDK2 | P24941 | 8/20 | 0.61 |
| ▸ | CDK4 | P11802 | 2/20 | 0.61 |
| ▸ | CDK7 | P50613 | 2/20 | 0.61 |
| ▸ | CDK9 | P50750 | 2/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.61 |
| ▸ | CCND1 | P24385 | 1/20 | 0.61 |
| ▸ | CCNH | P51946 | 1/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.60 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.57 |
| ▸ | STK17B | O94768 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CA9 | Q16790 | 4/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3865620 | 0.90 | STK17A (0.68) | CA2CDK1KDRCDK2CDK4 | |
| SCHEMBL4067086 | 0.89 | CA2 (0.66) | CA2CDK1KDRCDK2CDK4 | |
| SCHEMBL3873050 | 0.89 | STK17A (0.73) | CA2CDK1KDRCDK2CDK4 | |
| SCHEMBL4060838 | 0.88 | CA2 (0.62) | CA2CDK1KDRCDK2CDK4 | |
| SCHEMBL13901432 | 0.88 | CA2 (0.53) | CA2CDK1KDRCDK2CDK4 | |
| Hydrochloric Acid SCHEMBL3869305 | 0.88 | STK17A (0.71) | CA2CDK1KDRCDK2CDK4 | |
| SCHEMBL3867378 | 0.87 | CA2 (0.64) | CA2CDK1KDRCDK2CDK4 | |
| SCHEMBL4058029 | 0.87 | CA2 (0.67) | CA2CDK1KDRCDK2CDK4 | |
| SCHEMBL6448921 | 0.86 | CA2 (0.65) | CA2CDK1KDRCDK2CDK4 | |
| SCHEMBL4064853 | 0.85 | CA2 (0.61) | CA2CDK1KDRCDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1717396-A | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AG (DE) | 2006-01-04 | — | — | CN | claimed |
| US-20040186118-A1 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-09-23 | — | — | US | claimed |
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| CN-1717396-A | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AG (DE) | 2006-01-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186118-A1 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | DCK, PDPK1, DTYMK | CA2 3940/4885CDK1 237/4885KDR 645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.