Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5034056 | 0.83 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL650326 | 0.83 | NR1H2 (0.46) | CHRNB2CHRNA4CHRNB4CHRNA3GPR119 | |
| SCHEMBL652419 | 0.83 | NR1H2 (0.46) | CHRNB2CHRNA4CHRNB4CHRNA3GPR119 | |
| SCHEMBL3583185 | 0.82 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL652816 | 0.81 | GPR119 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3LCK | |
| SCHEMBL652549 | 0.81 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL650346 | 0.81 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL650044 | 0.79 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3GPR119 | |
| SCHEMBL653782 | 0.79 | NR1H2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3GPR119 | |
| SCHEMBL653781 | 0.79 | NR1H2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |