SCHEMBL6543258

SCHEMBL6543258

COc1ccc(OC)c(C(N)C=O)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.58
ADRA1A P35348 3/20 0.57
ADRA2A P08913 2/20 0.57
CYP2D6 P10635 2/20 0.57
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
MAPK1 P28482 1/20 0.55
BLM P54132 1/20 0.55
CA1 P00915 2/20 0.51
CA2 P00918 2/20 0.51
ACHE P22303 1/20 0.51
ALDH1A1 P00352 2/20 0.47
CA12 O43570 1/20 0.47
CA7 P43166 1/20 0.47
CA9 Q16790 1/20 0.47
CA14 Q9ULX7 1/20 0.47
HTR2A P28223 1/20 0.46
MAPT P10636 1/20 0.46
THRB P10828 1/20 0.46
LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4981765 0.82 HTT (0.66) HTTADRA1AADRA2ACYP2D6MEN1
SCHEMBL3610280 0.81 HTT (0.59) HTTADRA1AADRA2ACYP2D6MEN1
Hydrochloric Acid SCHEMBL5761162 0.80 ALDH1A1 (0.40) HTTADRA1AADRA2ACYP2D6MEN1
SCHEMBL28963070 0.79 HTT (0.58) HTTADRA1AADRA2ACYP2D6MEN1
SCHEMBL2928368 0.79 HTT (0.58) HTTADRA1AADRA2ACYP2D6MEN1
SCHEMBL5759427 0.78 CA1 (0.46) HTTMEN1KMT2ACA1CA2
SCHEMBL2498221 0.78 ADRA1A (0.74) HTTADRA1AADRA2ACYP2D6MEN1
Hydrochloric Acid SCHEMBL5756769 0.77 IDO1 (0.47) HTTMEN1KMT2ACA1CA2
SCHEMBL6500258 0.76 HTR2A (0.67) HTTADRA1AALDH1A1HTR2AGAA
SCHEMBL27546835 0.76 HTT (0.54) HTTADRA1AADRA2ACYP2D6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465860-A1 AN IMPROVED PROCESS FOR THE SYNTHESIS OF ( ) 2-AMINO-N-[2,(S,5-DIMETHOXYPHENYL)-2-HYDROXYETHYL] ACETAMIDE MONOHYDROCHLORIDE Sanmar Speciality Chemicals Ltd (IN) 2004-10-13 EP claimed
EP-1465860-A4 AN IMPROVED PROCESS FOR THE SYNTHESIS OF ( ) 2-AMINO-N-[2,(S,5-DIMETHOXYPHENYL)-2-HYDROXYETHYL] ACETAMIDE MONOHYDROCHLORIDE SANMAR SPECIALITY CHEMICALS LT (IN) 2004-10-13 EP claimed
WO-2004018409-A1 AN IMPROVED PROCESS FOR THE SYNTHESIS OF (±) 2-AMINO-N-[2,(S,5-DIMETHOXYPHENYL)-2-HYDROXYETHYL] ACETAMIDE MONOHYDROCHLORIDE SANMAR SPECIALITY CHEMICALS LTD (IN) 2004-03-04 WO claimed