Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787019 | 0.80 | MAOB (0.43) | ERN1L3MBTL1SMN1; SMN2LMNANPC1 | |
| SCHEMBL6088536 | 0.80 | MAOB (0.43) | ERN1L3MBTL1SMN1; SMN2LMNANPC1 | |
| SCHEMBL6091311 | 0.80 | MAOB (0.43) | ERN1L3MBTL1SMN1; SMN2LMNANPC1 | |
| SCHEMBL3200550 | 0.79 | ALDH1A1 (0.63) | BACE1ERN1HDAC8KDM4EL3MBTL1 | |
| SCHEMBL28277439 | 0.77 | BACE1 (0.46) | BACE1ERN1HDAC8KDM4ETDP1 | |
| SCHEMBL17192798 | 0.77 | BACE1 (0.50) | BACE1ERN1HDAC8TDP1L3MBTL1 | |
| SCHEMBL28276014 | 0.76 | BACE1 (0.45) | BACE1ERN1HDAC8KDM4ETDP1 | |
| SCHEMBL10791087 | 0.75 | BACE1 (0.48) | BACE1ERN1HDAC8TDP1L3MBTL1 | |
| SCHEMBL10009490 | 0.75 | BACE1 (0.49) | BACE1ERN1HDAC8KDM4EL3MBTL1 | |
| SCHEMBL20954376 | 0.75 | BACE1 (0.44) | BACE1ERN1HDAC8L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392659-A4 | METHODS OF MAKING INDAZOLES | ALCON INC (CH) | 2004-10-20 | — | — | EP | disclosed |
| EP-1392659-A1 | METHODS OF MAKING INDAZOLES | Alcon, Inc. (CH) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002098862-A1 | METHODS OF MAKING INDAZOLES | ALCON, INC. (CH) | 2002-12-12 | — | — | WO | disclosed |