Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | BACE1 | P56817 | 2/20 | 0.61 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438701 | 0.88 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1BACE1CA9SMN1; SMN2 | |
| SCHEMBL10791087 | 0.88 | BACE1 (0.48) | ALDH1A1L3MBTL1BACE1ERN1HDAC8 | |
| SCHEMBL10009490 | 0.87 | BACE1 (0.49) | ALDH1A1L3MBTL1BACE1ERN1HDAC8 | |
| SCHEMBL3218793 | 0.87 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1BACE1HDAC8CA9 | |
| SCHEMBL17192798 | 0.86 | BACE1 (0.50) | ALDH1A1L3MBTL1BACE1ERN1HDAC8 | |
| SCHEMBL18155193 | 0.86 | BACE1 (0.58) | ALDH1A1L3MBTL1BACE1NOX1HDAC8 | |
| SCHEMBL11934279 | 0.85 | BACE1 (0.48) | ALDH1A1L3MBTL1BACE1ERN1HDAC8 | |
| SCHEMBL3220878 | 0.85 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1BACE1CA9KMT2A | |
| SCHEMBL3200647 | 0.85 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1BACE1CA9SMN1; SMN2 | |
| SCHEMBL20954457 | 0.84 | BACE1 (0.48) | ALDH1A1L3MBTL1BACE1ERN1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323816-B1 | NOVEL PYRAZOLE DERIVATIVE | GREEN TECHNOLOGY CO LTD (JP) | 2019-07-03 | — | — | EP | disclosed |
| EP-3323816-A1 | NOVEL PYRAZOLE DERIVATIVE | Green Tech Co., Ltd. (JP) | 2018-05-23 | — | — | EP | disclosed |
| EP-2698368-B1 | NOVEL PYRAZOLE DERIVATIVE | GREEN TECHNOLOGY CO LTD (JP) | 2018-02-14 | — | — | EP | disclosed |
| US-9468632-B2 | Methods and compositions for targeting cancer stem cells | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-10-18 | — | — | US | disclosed |
| US-9468632-B2 | Methods and compositions for targeting cancer stem cells | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-10-18 | — | — | US | disclosed |
| CN-103717588-B | Pyrazole derivatives | 绿色科技株式会社 | 2016-08-03 | — | — | CN | disclosed |
| US-9399635-B2 | Pyrazole derivative | GREEN TECH CO., LTD. (JP) | 2016-07-26 | — | — | US | disclosed |
| US-20150297577-A1 | METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-10-22 | — | — | US | disclosed |
| US-20150297577-A1 | METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-10-22 | — | — | US | disclosed |
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20140088029-A1 | NOVEL PYRAZOLE DERIVATIVE | PHARMA EIGHT CO., LTD. (JP) | 2014-03-27 | — | — | US | disclosed |
| EP-2698368-A1 | NOVEL PYRAZOLE DERIVATIVE | Pharma Eight Co. Ltd (JP) | 2014-02-19 | — | — | EP | disclosed |
| CN-101558038-B | Curcumin derivative | TOKYO INST TECH | 2013-05-01 | — | — | CN | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
| CN-101558038-A | Novel curcumin derivative | TOKYO INST TECH (JP) | 2009-10-14 | — | — | CN | disclosed |
| CN-1829736-A | severe acute respiratory syndrome coronavirus | CHIRON CORP (US) | 2006-09-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | ALDH1A1 253/4885L3MBTL1 2164/4885BACE1 1/4885 |
| US-20150297577-A1 | METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS | MCL1, CD44, TP53 | ALDH1A1 268/4885L3MBTL1 2316/4885BACE1 3608/4885 |
| US-20140088029-A1 | NOVEL PYRAZOLE DERIVATIVE | PSEN2, MAPT, PSEN1 | ALDH1A1 675/4885L3MBTL1 4133/4885BACE1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.