Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6543810 | 0.92 | ESRRA (0.46) | HTTL3MBTL1NR1H4ESRRAALDH1A1 | |
| SCHEMBL6543839 | 0.85 | MAPT (0.40) | HTTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6544749 | 0.85 | ALDH1A1 (0.38) | HTTSMN1; SMN2MEN1KMT2ANR1H4 | |
| SCHEMBL6544430 | 0.84 | MMP13 (0.42) | SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL6543570 | 0.84 | MERTK (0.40) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3487495 | 0.84 | ALDH1A1 (0.41) | HTTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL6543834 | 0.84 | NR1H4 (0.35) | HTTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL27939756 | 0.84 | KMT2A (0.39) | HTTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3241737 | 0.83 | MEN1 (0.38) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6543994 | 0.82 | ESRRA (0.39) | HTTSMN1; SMN2MEN1KMT2AGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1022272-B1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | SANKYO CO (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6432993-B1 | BENZIMIDAZOLE OR IMIDAZO(4,5-B)PYRIDINE DERIVATES; IMMUNOMODULATORS; ALDOSE REDUCTASE AND LIPOXYGENASE INHIBITORS; DIABETES; PREVENTS LIPID PEROXIDATION; ANTILIPEMIC, HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1022272-A1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |