Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.55 |
| ▸ | REN | P00797 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750903 | 0.98 | ACE (0.56) | ACERENLMNACYP2C19HSD17B10 | |
| SCHEMBL187408 | 0.98 | ACE (0.56) | ACERENLMNACYP2C19HSD17B10 | |
| SCHEMBL1543546 | 0.98 | ACE (0.56) | ACERENLMNACYP2C19HSD17B10 | |
| Ammonia Solution, Strong SCHEMBL29036066 | 0.95 | ACE (0.55) | ACERENLMNACYP2C19HSD17B10 | |
| Ammonia Solution, Strong SCHEMBL29036064 | 0.95 | ACE (0.55) | ACERENLMNACYP2C19HSD17B10 | |
| Bicarbonate SCHEMBL7972998 | 0.93 | ACE (0.53) | ACERENLMNACYP2C19HSD17B10 | |
| SCHEMBL258790 | 0.91 | ACE (0.50) | ACEREN | |
| SCHEMBL6478173 | 0.91 | ACE (0.50) | ACEREN | |
| SCHEMBL1950731 | 0.91 | ACE (0.50) | ACEREN | |
| Bicarbonate SCHEMBL7973000 | 0.90 | ACE (0.50) | ACERENLMNACYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-A1 | 2-IMINOPYRROLIDINE DERIVATES | Eisai Co., Ltd. (JP) | 2004-02-25 | — | — | EP | disclosed |