Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.53 |
| ▸ | REN | P00797 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543546 | 0.96 | ACE (0.56) | ACERENLMNACYP2C19HSD17B10 | |
| SCHEMBL187408 | 0.96 | ACE (0.56) | ACERENLMNACYP2C19HSD17B10 | |
| SCHEMBL750903 | 0.96 | ACE (0.56) | ACERENLMNACYP2C19HSD17B10 | |
| Ammonia Solution, Strong SCHEMBL29036064 | 0.93 | ACE (0.55) | ACERENLMNACYP2C19HSD17B10 | |
| Ammonia Solution, Strong SCHEMBL29036066 | 0.93 | ACE (0.55) | ACERENLMNACYP2C19HSD17B10 | |
| Bromide SCHEMBL6544002 | 0.93 | ACE (0.55) | ACERENLMNACYP2C19HSD17B10 | |
| SCHEMBL258790 | 0.89 | ACE (0.50) | ACEREN | |
| SCHEMBL6478173 | 0.89 | ACE (0.50) | ACEREN | |
| SCHEMBL1950731 | 0.89 | ACE (0.50) | ACEREN | |
| Bicarbonate SCHEMBL7973000 | 0.88 | ACE (0.50) | ACERENLMNACYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001029050-A2 | CONDENSED PYRROLE DERIVATIVES AS NEURAMINIDASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-04-26 | — | — | WO | disclosed |