SCHEMBL6544067

SCHEMBL6544067

CC(C)(Oc1cccc(CNCCc2nc3ccccc3o2)c1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PPARG P37231 10/20 0.56
PPARA Q07869 10/20 0.56
PPARD Q03181 4/20 0.56
MAPT P10636 1/20 0.43
P2RY14 Q15391 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6542939 0.94 PPARG (0.56) PPARGPPARAPPARDMAPT
SCHEMBL6542943 0.94 PPARA (0.56) PPARGPPARAPPARDMAPT
SCHEMBL6543077 0.93 PPARG (0.60) PPARGPPARAPPARDMAPTP2RY14
SCHEMBL6544090 0.93 PPARG (0.55) PPARGPPARAPPARDMAPT
SCHEMBL6544098 0.91 PPARG (0.61) PPARGPPARAPPARDMAPT
SCHEMBL6544270 0.89 PPARA (0.54) PPARGPPARAPPARDMAPTKDM4E
SCHEMBL6544109 0.89 PPARG (0.59) PPARGPPARAPPARDMAPTKDM4E
SCHEMBL6543898 0.88 PPARG (0.58) PPARGPPARAPPARDMAPTKDM4E
SCHEMBL6544252 0.88 PPARG (0.62) PPARGPPARAPPARDMAPT
SCHEMBL6542989 0.87 PPARG (0.51) PPARGPPARAPPARDP2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1433786-A1 Benzoxazole compound and pharmaceutical composition containing the compound Kowa Company Ltd. (JP) 2004-06-30 EP disclosed
US-6653334-B1 Electively activate peroxisome proliferator activated receptors KOWA CO., LTD. (JP) 2003-11-25 US disclosed