Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | ESRRA | P11474 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6544301 | 1.00 | PTGS2 (0.48) | PTGS2PTGS1ESRRAPPARGHPGD | |
| SCHEMBL6544823 | 0.85 | ESRRA (0.52) | ESRRAPPARG | |
| SCHEMBL6543658 | 0.81 | PPARG (0.72) | ESRRAPPARG | |
| Hydrochloric Acid SCHEMBL6544222 | 0.80 | PPARG (0.71) | ESRRAPPARG | |
| SCHEMBL6697822 | 0.78 | ESRRA (0.51) | ESRRAPPARG | |
| SCHEMBL6699619 | 0.77 | ESRRA (0.48) | ESRRAPPARG | |
| Hydrochloric Acid SCHEMBL6700550 | 0.76 | ESRRA (0.47) | ESRRAPPARG | |
| SCHEMBL6544302 | 0.74 | PTGS2 (0.48) | PTGS2PTGS1PPARGHPGDPIM1 | |
| SCHEMBL6544220 | 0.73 | ESRRA (0.41) | ESRRAPPARGHPGDPOLB | |
| SCHEMBL6701377 | 0.72 | ESRRA (0.44) | ESRRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1022272-B1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | SANKYO CO (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6432993-B1 | BENZIMIDAZOLE OR IMIDAZO(4,5-B)PYRIDINE DERIVATES; IMMUNOMODULATORS; ALDOSE REDUCTASE AND LIPOXYGENASE INHIBITORS; DIABETES; PREVENTS LIPID PEROXIDATION; ANTILIPEMIC, HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1022272-A1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |