Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 14/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6544301 | 0.85 | PTGS2 (0.48) | ESRRAPPARG | |
| SCHEMBL6544303 | 0.85 | PTGS2 (0.48) | ESRRAPPARG | |
| SCHEMBL6697822 | 0.85 | ESRRA (0.51) | ESRRAPPARG | |
| SCHEMBL6699619 | 0.84 | ESRRA (0.48) | ESRRAPPARG | |
| Hydrochloric Acid SCHEMBL6700550 | 0.83 | ESRRA (0.47) | ESRRAPPARG | |
| SCHEMBL6543658 | 0.80 | PPARG (0.72) | ESRRAPPARG | |
| Hydrochloric Acid SCHEMBL6544222 | 0.79 | PPARG (0.71) | ESRRAPPARG | |
| SCHEMBL6544220 | 0.79 | ESRRA (0.41) | ESRRAPPARGTP53MAPT | |
| SCHEMBL6701377 | 0.78 | ESRRA (0.44) | ESRRAPPARGNPC1RAB9A | |
| SCHEMBL6703679 | 0.77 | ESRRA (0.42) | ESRRAPPARGNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1022272-B1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | SANKYO CO (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6432993-B1 | BENZIMIDAZOLE OR IMIDAZO(4,5-B)PYRIDINE DERIVATES; IMMUNOMODULATORS; ALDOSE REDUCTASE AND LIPOXYGENASE INHIBITORS; DIABETES; PREVENTS LIPID PEROXIDATION; ANTILIPEMIC, HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1022272-A1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |