Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7197406 | 1.00 | MAPT (0.47) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL16021883 | 1.00 | MAPT (0.47) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL16021889 | 0.85 | KMT2A (0.45) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL16021885 | 0.85 | KMT2A (0.45) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL616620 | 0.83 | MAPT (0.53) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL60357 | 0.83 | MAPT (0.47) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL1068997 | 0.82 | KMT2A (0.50) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL7019907 | 0.81 | MAPT (0.45) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL6874329 | 0.81 | MAPT (0.45) | MAPTKMT2ACYP2C19HIF1AHDAC3 | |
| SCHEMBL17093302 | 0.81 | MAPT (0.45) | MAPTKMT2ACYP2C19HIF1AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104744231-A | Method for splitting 2-hydracrylicacid racemate | TIANJIN INST PHARM RESEARCH | 2015-07-01 | — | — | CN | claimed |
| CN-103086877-A | Splitting method of 2-hydracrylic acid racemic mixture | ZHEJIANG HUAHAI PHARM CO LTD | 2013-05-08 | — | — | CN | claimed |
| EP-1124782-B1 | METHOD FOR RACEMATE SPLITTING OF 2-HYDROXYPROPIONIC ACIDS | ABBOTT GMBH & CO KG (DE) | 2004-01-02 | — | — | EP | claimed |
| US-6559338-B1 | Method for racemate splitting of 2-hydroxypropionic acids | BASF AKTIENGESELLSCHAFT (DE) | 2003-05-06 | — | — | US | claimed |
| CN-105801404-B | A kind of S-2- hydroxy-3-methoxy -3,3- diphenyl-propionic acid and preparation method thereof | 辽宁远大诺康生物制药有限公司 | 2019-01-08 | — | — | CN | disclosed |
| CN-103086877-B | A kind of method for splitting of 2 hydracrylic acid class racemoid | 浙江华海药业股份有限公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-105801404-A | S-2-hydroxy-3-methoxy-3, 3-dibenzylpropionic acid and preparation method thereof | 辽宁诺康生物制药有限责任公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-104744231-A | Method for splitting 2-hydracrylicacid racemate | TIANJIN INST PHARM RESEARCH | 2015-07-01 | — | — | CN | disclosed |
| US-20140256004-A1 | Process for the Preparation of an Endothelin Receptor Antagonist | CIPLA LIMITED (IN) | 2014-09-11 | — | — | US | disclosed |
| US-20130184490-A1 | PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID | NATCO PHARMA LIMITED (IN) | 2013-07-18 | — | — | US | disclosed |
| CN-103086877-A | Splitting method of 2-hydracrylic acid racemic mixture | ZHEJIANG HUAHAI PHARM CO LTD | 2013-05-08 | — | — | CN | disclosed |
| WO-2012017441-A1 | IMPROVED PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID | NATCO PHARMA LIMITED (IN) | 2012-02-09 | — | — | WO | disclosed |
| US-6686369-B1 | α-hydrdroxylic acid derivatives, their production and use | ABBOTT GMBH & CO., KG (DE) | 2004-02-03 | — | — | US | disclosed |
| EP-1124782-B1 | METHOD FOR RACEMATE SPLITTING OF 2-HYDROXYPROPIONIC ACIDS | ABBOTT GMBH & CO KG (DE) | 2004-01-02 | — | — | EP | disclosed |
| US-6646152-B1 | Decyclization of glycidyl ester using organoaluminum reagent; no side reactions | ABBOTT GMBH & CO. KG (DE) | 2003-11-11 | — | — | US | disclosed |
| US-6559338-B1 | Method for racemate splitting of 2-hydroxypropionic acids | BASF AKTIENGESELLSCHAFT (DE) | 2003-05-06 | — | — | US | disclosed |
| US-6448248-B1 | ENDOTHELIN IS INVOLVED IN A NUMBER OF ILLNESSES INCLUDING: HYPERTENSION, ACUTE MYOCARDIAL INFARCT, PULMONARY HYPERTENSION, RAYNAUD'S SYNDROME, CEREBRAL VASOSPASMS, STROKE, BENIGN PROSTATE HYPERTROPHY, ATHEROSCLEROSIS AND ASTHMA | ABBOTT LABORATORIES | 2002-09-10 | — | — | US | disclosed |
| EP-1124782-A1 | METHOD FOR RACEMATE SPLITTING OF 2-HYDROXYPROPIONIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026170-A1 | METHOD FOR RACEMATE SPLITTING OF 2-HYDROXYPROPIONIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-11 | — | — | WO | disclosed |
| CN-1247533-A | Heterocyclic carboxylic acid derivatives, their preparation and their use as endothelin (endothielin) receptor antagonists | BASF AG (DE) | 2000-03-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130184490-A1 | PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID | PAH, TGFB2, TGFBR2 | MAPT 4545/4885KMT2A 283/4885CYP2C19 1741/4885 |
| US-20140256004-A1 | Process for the Preparation of an Endothelin Receptor Antagonist | EDNRB, EDNRA, AGTR1 | MAPT 4679/4885KMT2A 2150/4885CYP2C19 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.