Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366561 | 0.87 | KMT2A (0.48) | KMT2AKCNN4HDAC3HDAC4HDAC1 | |
| SCHEMBL18595880 | 0.83 | KMT2A (0.48) | KMT2AKCNN4HDAC3HDAC4HDAC1 | |
| SCHEMBL7197406 | 0.82 | MAPT (0.47) | KMT2AKCNN4HDAC3HDAC4HDAC1 | |
| SCHEMBL16021883 | 0.82 | MAPT (0.47) | KMT2AKCNN4HDAC3HDAC4HDAC1 | |
| SCHEMBL6544643 | 0.82 | MAPT (0.47) | KMT2AKCNN4HDAC3HDAC4HDAC1 | |
| SCHEMBL24517965 | 0.81 | KMT2A (0.47) | KMT2AKCNN4HDAC3HDAC4HDAC1 | |
| SCHEMBL2354447 | 0.81 | KMT2A (0.47) | KMT2AKCNN4CES1KIF11TSHR | |
| SCHEMBL571027 | 0.81 | KMT2A (0.47) | KMT2AKCNN4CES1KIF11TSHR | |
| SCHEMBL6779283 | 0.81 | PIN1 (0.49) | KMT2ACYP2C19HIF1ATSHRALDH1A1 | |
| SCHEMBL27575494 | 0.81 | KMT2A (0.47) | KMT2AKCNN4HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130317044-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2013-11-28 | — | — | US | disclosed |
| US-20130184490-A1 | PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID | NATCO PHARMA LIMITED (IN) | 2013-07-18 | — | — | US | disclosed |
| US-8349843-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20120088911-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2012-04-12 | — | — | US | disclosed |
| WO-2012017441-A1 | IMPROVED PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID | NATCO PHARMA LIMITED (IN) | 2012-02-09 | — | — | WO | disclosed |
| US-20110178294-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2011-07-21 | — | — | US | disclosed |
| US-RE42477-E1 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-06-21 | — | — | US | disclosed |
| US-RE42462-E1 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-06-14 | — | — | US | disclosed |
| US-7863445-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-03-25 | — | — | US | disclosed |
| US-6686369-B1 | α-hydrdroxylic acid derivatives, their production and use | ABBOTT GMBH & CO., KG (DE) | 2004-02-03 | — | — | US | disclosed |
| US-6600043-B2 | Pyramidine or triazine derivatives which specifically inhibit the binding of endothelin to the receptor | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-29 | — | — | US | disclosed |
| US-20020052495-A1 | Novel carboxylic acid derivatives, their preparation and use | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2002-05-02 | — | — | US | disclosed |
| US-6197958-B1 | CYCLOPENTAPYRIMIDINE DERIVATIVES; ENDOTHELIN RECEPTOR INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-06 | — | — | US | disclosed |
| US-6030975-A | ANTAGONIST OF ENDOTHELINS, I.E. INHIBITION OF BINDING WITH RECEPTOR; ANTITUMOR AND -CARCINOGENIC AGENTS; SIDE EFFECT REDUCTION | BASF AKTIENGESELLSCHAFT (DE) | 2000-02-29 | — | — | US | disclosed |
| EP-0969841-A1 | USE OF CARBOXYLIC ACID DERIVATIVES FOR TREATING CANCER | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| US-5969134-A | CARDIOVASCULAR DISORDERS, VASOCONSTRICTION, HYPOTENSIVE AGENTS AND RELEASE OF ENDOTHELINS | BASF AKTIENGESELLSCHAFT (DE) | 1999-10-19 | — | — | US | disclosed |
| US-5932730-A | Carboxylic acid derivatives, their preparation and use | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-03 | — | — | US | disclosed |
| CN-1222146-A | Novel alpha-hydroxy acid derivatives, their preparation and their use | BASF AG (DE) | 1999-07-07 | — | — | CN | disclosed |
| WO-1998041206-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE IN TREATING CANCER | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088911-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | KMT2A 2424/4885KCNN4 4240/4885HDAC3 662/4885 |
| US-20130184490-A1 | PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID | PAH, TGFB2, TGFBR2 | KMT2A 283/4885KCNN4 2011/4885HDAC3 114/4885 |
| US-20020052495-A1 | Novel carboxylic acid derivatives, their preparation and use | HCAR1, HCAR2, SUCNR1 | KMT2A 2416/4885KCNN4 4551/4885HDAC3 388/4885 |
| US-20130317044-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | KMT2A 2152/4885KCNN4 4213/4885HDAC3 725/4885 |
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | KMT2A 2152/4885KCNN4 4213/4885HDAC3 725/4885 |
| US-20110178294-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | KMT2A 2152/4885KCNN4 4213/4885HDAC3 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.